Respirazione cellulare e cancro
Nuove importanti evidenze scientifiche
Sulla prestigiosa rivista scientifica Nature del 1 settembre scorso è stato pubblicato un importante articolo:
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
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Bernard Thienpont, Jessica Steinbacher, Hui Zhao, Flora D’Anna, Anna Kuchnio, Athanasios Ploumakis, Bart Ghesquière, Laurien Van Dyck, Bram Boeckx, Luc Schoonjans, Els Hermans, Frederic Amant, Vessela N. Kristensen, Kian Peng Koh, Massimiliano Mazzone, Mathew L. Coleman, Thomas Carell, Peter Carmeliet & Diether Lambrechts
Affiliations Contributions Corresponding authors
Nature 537, 63–68 (01 September 2016) doi:10.1038/nature19081
Received 19 June 2015 Accepted 05 July 2016 Published online 17 August 2016 Corrected online 16 September 2016
Gli autori hanno dimostrato la strettissima correlazione tra respirazione cellulare e cancro. Otto Warburg nel 1931 ha ottenuto il premio Nobel per avere dimostrato che la scarsa ossigenazione cellulare causava il cancro. L’ozonoterapia aumenta la respirazione cellulare : per questi motivi noi proponiamo l’ozonoterapia nella prevenzione del cancro e come cura complementare quando questo si è manifestato. Diversi autori hanno già dimostrato che l’ozonoterapia aumenta l’efficacia di radio e chemio terapia, diminuendone gli effetti collaterali.
Hypermethylation of the promoters of tumour suppressor genes represses transcription of these genes, conferring growth advantages to cancer cells. How these changes arise is poorly understood. Here we show that the activity of oxygen-dependent ten-eleven translocation (TET) enzymes is reduced by tumour hypoxia in human and mouse cells. TET enzymes catalyse DNA demethylation through 5-methylcytosine oxidation. This reduction in activity occurs independently of hypoxia-associated alterations in TET expression, proliferation, metabolism, hypoxia-inducible factor activity or reactive oxygen species, and depends directly on oxygen shortage. Hypoxia-induced loss of TET activity increases hypermethylation at gene promoters in vitro. In patients, tumour suppressor gene promoters are markedly more methylated in hypoxic tumour tissue, independent of proliferation, stromal cell infiltration and tumour characteristics.